研究成果

KEAP1 retention in phase-separated p62 bodies drives liver damage under autophagy-deficient conditions
Takada S, Shinomiya N, Mao G, Tsuchiya H, Koga T, Komatsu-Hirota S, Sou Y-S, Abe M, Ryzhii E, Suzuki M, Nakao M, Waguri, Morishita H, Komatsu M.
EMBO Rep (2025)


Sleep homeostasis in lizards and the role of the cortex
Hatori S, Yamaguchi ST, Kobayashi R, Okamoto K, Zhou Z, Kotake KT, Matsui F, Hioki H, Norimoto H.
Proc Natl Acad Sci U S A. 122(16):e2415929122 (2025)


Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines.
Ageta-Ishihara N, Fukazawa Y, Arima-Yoshida F, Okuno H, Ishii Y, Takao K, Konno K, Fujishima K, Ageta H, Hioki H, Tsuchida K, Sato Y, Kengaku M, Watanabe M, Watabe AM, Manabe T, Miyakawa T, Inokuchi K, Bito H, Kinoshita M.
Cell Rep. 44(3):115352 (2025).


NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination
Jeon P, Ham HJ, Choi H, Park S, Jang JW, Park SW, Cho DH, Lee HJ, Song HK, Komatsu M, Han D, Jang DJ, Lee JA.
Nat Commun. 15(1):10925 (2024).


Macronucleophagy maintains cell viability under nitrogen starvation by modulating micronucleophagy
Li Z. Mochida K, Nakatogawa H. 
Nat Commun. 15(1):10670 (2024).


Clustering lysosomes around the MTOC: a promising strategy for SNCA/alpha-synuclein breakdown leading to parkinson disease treatment
Sasazawa Y, Date Y, Hattori N, Saiki S.
Autophagy 20(12): 2839–2840 (2024) 


Unlocking the potential of large-scale 3D imaging with tissue clearing techniques.
Susaki EA.
Microscopy Sep 28:dfae046 (2024)


Realization of cellomics to dive into the whole-body or whole-organ cell cloud.
Mitani TT, Susaki EA, Matsumoto K, Ueda HR.
Nat Methods 21:1138-1142 (2024)


descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques
Otomo K, Omura T, Nozawa Y, Edwards SJ, Sato Y, Saito Y, Yagishita S, Uchida H, Watakabe Y, Naitou K, Yanai R, Sahara N, Takagi S, Katayama R, Iwata Y, Shiokawa T, Hayakawa Y, Otsuka K, Watanabe-Takano H, Haneda Y, Fukuhara S, Fujiwara M, Nii T, Meno C, Takeshita N, Yashiro K, Rosales Rocabado JM, Kaku M, Yamada T, Oishi Y, Koike H, Cheng Y, Sekine K, Koga JI, Sugiyama K, Kimura K, Karube F, Kim H, Manabe I, Nemoto T, Tainaka K, Hamada A, Brismar H, Susaki EA
Nat Commun. 15(1):4941 (2024)


Ichimura Y. and Komatsu M.
A redox-independent stress response mediated by phase-separated SQSTM1/p62
Autophagy Reports. Vol.3 (2024)


Ichimura Y, Sugiura Y, Katsuragi Y, Sou YS, Uemura T, Tamura N, Komatsu-Hirota S, Ueno T, Koike M, Waguri S, Komatsu M.
Loss of SPNS1, a lysosomal transporter, in the nervous systemcauses dysmyelination and white matter dysplasia
eLife. Reviewed Preprint. Jul 4, 2024.